PT-141 (Bremelanotide) Research Peptide
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist studied for MC3R and MC4R signalling within the central melanocortin system. Manufactured in our Dallas, Texas cGMP facility with ≥99% HPLC purity and a batch-specific Certificate of Analysis. Each lot ships with its batch COA and same-day cold-chain dispatch across the US.
For laboratory research use only. Not for human or animal consumption.
$ 75.00 - or subscribe
| Quantity | Price | Discount |
|---|---|---|
| 3-5 | $ 67.50 | 10% |
| 6-9 | $ 63.75 | 15% |
| 10+ | $ 60.00 | 20% |
Description
Quick answer: PT-141 (bremelanotide) is a synthetic cyclic heptapeptide and melanocortin receptor agonist, studied mainly at the MC3R and MC4R receptors in hypothalamic signalling research. LiveWell makes it in its own Dallas cGMP facility, tests every lot to 99%+ HPLC purity with a batch COA, and supplies it for in-vitro laboratory research only.
PT-141 Research Peptide — Manufactured in the USA
PT-141, systematically named bremelanotide, is a synthetic cyclic heptapeptide analogue of alpha-melanocyte-stimulating hormone (α-MSH). It functions as a melanocortin receptor agonist with documented activity at MC1R, MC3R, MC4R, and MC5R, and published research concentrates on the MC3R and MC4R subtypes expressed in hypothalamic and limbic tissue. Structurally, PT-141 is a metabolite of Melanotan-2, formed through hydrolysis of the MT-2 lactam bridge, with reduced peripheral MC1R activity relative to its parent compound.
Every vial is synthesized, lyophilized, and tested in our own cGMP facility in Dallas, Texas — we are the manufacturer, not a reseller.
Chemical Information
- Name: PT-141 (bremelanotide)
- CAS Number: 189691-06-3
- Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH
- Molecular Formula: C₅₀H₆₈N₁₄O₁₀
- Molecular Weight: ~1025.2 g/mol
- Form: Lyophilized powder
- Purity: ≥99% (HPLC)
- Origin: Synthesized in Dallas, Texas, USA
Why Researchers Study PT-141
PT-141 occupies a distinctive position in melanocortin pharmacology for two reasons. First, it crosses the blood-brain barrier, which distinguishes it from many peripherally acting peptides. Second, its mechanism is centrally mediated through G-protein-coupled melanocortin receptors rather than through vascular pathways — a property that has made it a useful tool compound for investigators separating central signalling from peripheral mechanisms in comparative study designs.
Published research areas include:
- Receptor pharmacology — binding and functional assays characterising subtype selectivity across the melanocortin receptor family, frequently using cAMP accumulation as the downstream readout
- Structure-selectivity relationships — comparative work with Melanotan-2 identifying which structural features drive MC1R versus MC3R/MC4R engagement
- Central nervous system signalling — preclinical models examining hypothalamic neuronal activation following MC4R agonism
- Genetic validation — receptor loss-of-function models identifying MC4R as the primary mediating target
For a fuller literature summary, see our reference article on PT-141 melanocortin receptor research.
Quality and Testing
Receptor-binding studies depend on precise sequence identity — closely related melanocortin analogues produce measurably different selectivity profiles, and the very distinction between PT-141 and Melanotan-2 illustrates the point. Every LiveWell batch therefore passes four-point analytical testing:
- HPLC — purity confirmation, ≥99%
- Mass spectrometry — sequence identity verification
- LAL testing — endotoxin limits
- Water content analysis — lyophilization quality
Batch-specific documentation is published openly on our COA page — not supplied on request only. Match the lot number on your vial to its certificate before use.
Handling and Storage
- Store lyophilized vials refrigerated at 2–8°C, protected from light; longer-term storage at −20°C is common practice
- Reconstitute with bacteriostatic water; reconstituted material has a considerably shorter storage window
- Cyclic peptides are sensitive to repeated freeze-thaw cycling — aliquot accordingly
- Follow your laboratory’s standard handling and disposal protocol
Regulatory Status
The bremelanotide molecule exists in an FDA-approved prescription pharmaceutical formulation, approved in 2019 for a specific clinical indication and available only through licensed prescribers. The research-grade PT-141 sold here is not that product. It is a laboratory research material — not manufactured or approved for pharmaceutical or clinical use, not a substitute for any prescription medication, and not intended for human or animal administration. No comparison to any approved pharmaceutical product is made or implied.
Frequently Asked Questions
What is PT-141?
PT-141 (bremelanotide) is a synthetic cyclic heptapeptide analogue of α-MSH, CAS 189691-06-3, molecular weight approximately 1025.2 g/mol. It functions as a melanocortin receptor agonist and is supplied as lyophilized powder for laboratory research only.
Which receptors does PT-141 act on?
Binding assays report activity at MC1R, MC3R, MC4R, and MC5R. Published research concentrates on MC3R and MC4R, the subtypes most densely expressed in hypothalamic and limbic tissue.
How does PT-141 differ from Melanotan-2?
PT-141 is a metabolite of Melanotan-2, formed by hydrolysis of the MT-2 lactam bridge. It shows reduced activity at peripheral MC1R while retaining central MC3R and MC4R engagement, which is why the two are often studied in parallel.
Is this the same as the approved medication?
No. An FDA-approved prescription formulation of bremelanotide exists for a specific clinical indication. Research-grade PT-141 is a separate laboratory material — not manufactured or approved for pharmaceutical use, and not a substitute for any prescription medication.
How is purity verified?
Every batch passes HPLC purity testing (≥99%), mass-spectrometry identity confirmation, LAL endotoxin testing, and water-content analysis. The batch-specific COA is published on our COA page and matches the lot number on your vial.
How should PT-141 be stored?
Store lyophilized material refrigerated at 2–8°C protected from light, or at −20°C for longer-term storage. Reconstitute with bacteriostatic water and aliquot to minimise freeze-thaw cycling.
Related Research Compounds
KPV (α-MSH fragment) · Bacteriostatic Water · All Research Vials · Certificates of Analysis
For laboratory research use only. This product is designated solely as a research chemical for in-vitro laboratory use. Administration to humans or animals is prohibited. It is not a drug, food, or cosmetic and must not be misrepresented, improperly used, or mislabeled as such. The FDA has not evaluated statements on this page. No therapeutic claims are made or implied.
